Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17302276 | 1.00 | PRMT5 (0.34) | PRMT5WDR77IRAK4SRCTP53 | |
| SCHEMBL23120133 | 0.90 | PRMT5 (0.42) | PRMT5WDR77ADK | |
| SCHEMBL30941081 | 0.90 | PRMT5 (0.42) | PRMT5WDR77ADK | |
| SCHEMBL9285084 | 0.86 | PRMT5 (0.37) | PRMT5WDR77IRAK4 | |
| SCHEMBL9282147 | 0.86 | PRMT5 (0.37) | PRMT5WDR77IRAK4 | |
| SCHEMBL17302255 | 0.85 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL15381065 | 0.85 | NNMT (0.35) | ADK | |
| SCHEMBL17302256 | 0.84 | PRMT5 (0.30) | PRMT5WDR77 | |
| SCHEMBL9288000 | 0.82 | PRMT5 (0.36) | PRMT5WDR77IRAK4SRCTP53 | |
| SCHEMBL9286844 | 0.82 | PRMT5 (0.36) | PRMT5WDR77IRAK4SRCTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394310-B2 | Carbocycle-substituted purine and 7-deazapurine compounds | Epizyme, Inc. (US) | 2016-07-19 | — | — | US | disclosed |
| WO-2012075492-A2 | CARBOCYCLE-SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | Epizyme, Inc. (US) | 2012-06-07 | — | — | WO | disclosed |