Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 12/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 12/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.33 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.33 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9285084 | 1.00 | PRMT5 (0.37) | PRMT5WDR77IRAK4NAE1CA2 | |
| SCHEMBL23121274 | 0.89 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL9286844 | 0.87 | PRMT5 (0.36) | PRMT5WDR77IRAK4ADORA3ADORA1 | |
| SCHEMBL9288000 | 0.87 | PRMT5 (0.36) | PRMT5WDR77IRAK4ADORA3ADORA1 | |
| SCHEMBL17302276 | 0.86 | PRMT5 (0.34) | PRMT5WDR77IRAK4 | |
| SCHEMBL17936459 | 0.86 | PRMT5 (0.34) | PRMT5WDR77IRAK4 | |
| SCHEMBL9287692 | 0.84 | ADK (0.46) | PRMT5WDR77 | |
| SCHEMBL30941131 | 0.83 | NNMT (0.39) | PRMT5WDR77 | |
| SCHEMBL23776516 | 0.83 | NNMT (0.39) | PRMT5WDR77 | |
| SCHEMBL23120565 | 0.79 | PRMT5 (0.48) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646441-A2 | CARBOCYCLE-SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012075492-A2 | CARBOCYCLE-SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | Epizyme, Inc. (US) | 2012-06-07 | — | — | WO | disclosed |