Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 8/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18905429 | 0.83 | SLC2A1 (0.44) | MEN1KMT2ANR5A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19043224 | 0.80 | SLC2A1 (0.42) | SLC2A1APP | |
| SCHEMBL6055165 | 0.80 | MEN1 (0.59) | MEN1KMT2AALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL30567457 | 0.79 | SLC2A1 (0.50) | NR5A1ALDH1A1SMN1; SMN2SLC2A1LTA4H | |
| SCHEMBL7985189 | 0.77 | HRH3 (0.57) | MEN1KMT2AALDH1A1LTA4H | |
| SCHEMBL9380552 | 0.77 | SLC2A1 (0.51) | NR5A1SMN1; SMN2SLC2A1LTA4H | |
| SCHEMBL9498490 | 0.77 | NR5A1 (0.58) | NR5A1SLC2A1LTA4H | |
| SCHEMBL18905262 | 0.77 | MEN1 (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2SLC2A1 | |
| SCHEMBL21467376 | 0.76 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2APP | |
| SCHEMBL9499186 | 0.76 | LTA4H (0.52) | NR5A1SMN1; SMN2SLC2A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3078373-A1 | 2-ACYLAMINOPROPANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR | Genzyme Corporation (US) | 2016-10-12 | — | — | EP | disclosed |
| EP-2594564-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2016-09-28 | — | — | EP | disclosed |
| EP-2594562-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2016-07-20 | — | — | EP | disclosed |