Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 5/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.47 |
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793998 | 0.94 | SMARCA2 (0.49) | SMARCA2SMARCA4GRM5LRRK2HDAC4 | |
| SCHEMBL1799079 | 0.91 | GRM5 (0.46) | SMARCA2SMARCA4GRM5LRRK2HDAC4 | |
| SCHEMBL1794469 | 0.89 | SMARCA2 (0.56) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1796453 | 0.88 | SMARCA2 (0.61) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1794228 | 0.86 | SMARCA2 (0.58) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1795661 | 0.84 | SORT1 (0.46) | SMARCA2SMARCA4GRM5LRRK2HDAC4 | |
| SCHEMBL1797503 | 0.84 | SMARCA2 (0.60) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1796521 | 0.84 | GRM5 (0.50) | GRM5LRRK2HDAC4HDAC6GRM4 | |
| SCHEMBL7911154 | 0.82 | LRRK2 (0.55) | SMARCA2SMARCA4GRM5LRRK2GRM4 | |
| SCHEMBL1798756 | 0.81 | GRM5 (0.54) | SMARCA2SMARCA4GRM5HDAC4SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |