Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 4/20 | 0.60 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.60 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.51 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796453 | 0.96 | SMARCA2 (0.61) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1794469 | 0.95 | SMARCA2 (0.56) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1793750 | 0.94 | SORT1 (0.53) | SMARCA2SMARCA4SORT1GRM5ATR | |
| SCHEMBL1794228 | 0.90 | SMARCA2 (0.58) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1798756 | 0.84 | GRM5 (0.54) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1793992 | 0.84 | SMARCA2 (0.47) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1795233 | 0.84 | GRM5 (0.56) | SMARCA2SMARCA4SORT1GRM5ATR | |
| SCHEMBL1795467 | 0.84 | SORT1 (0.50) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1797439 | 0.84 | SMARCA2 (0.49) | SMARCA2SMARCA4SORT1GRM5HDAC4 | |
| SCHEMBL1799079 | 0.84 | GRM5 (0.46) | SMARCA2SMARCA4SORT1GRM5ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |