SCHEMBL17945643

SCHEMBL17945643

COC(=O)C1CCN(C(=O)[C@H](Cc2ccc(-c3ncc(Br)cn3)cc2)NC(=O)c2ccc(C(C)(C)C)s2)C1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 4/20 0.39
▸ FPR2 P25090 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ PLAU P00749 4/20 0.37
▸ PLG P00747 2/20 0.37
▸ ITGB3 P05106 2/20 0.35
▸ ITGA2B P08514 2/20 0.35
▸ PRCP P42785 1/20 0.35
▸ TMPRSS15 P98073 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ ACACB O00763 1/20 0.35
▸ ACKR3 P25106 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28532158 1.00 F10 (0.39) F10FPR2ALDH1A1HTTSMN1; SMN2
SCHEMBL28532160 1.00 F10 (0.39) F10FPR2ALDH1A1HTTSMN1; SMN2
SCHEMBL16306070 1.00 F10 (0.39) F10FPR2ALDH1A1HTTSMN1; SMN2
SCHEMBL17834369 0.94 ACACB (0.41) F10FPR2ITGB3ITGA2BPRCP
SCHEMBL17468537 0.94 FPR2 (0.34) F10FPR2ALDH1A1HTTSMN1; SMN2
SCHEMBL17492936 0.94 FPR2 (0.34) F10FPR2ALDH1A1HTTSMN1; SMN2
SCHEMBL16342611 0.92 PRCP (0.37) F10FPR2PLAUPLGITGB3
SCHEMBL22150105 0.92 PRCP (0.37) F10FPR2PLAUPLGITGB3
SCHEMBL16342612 0.92 PRCP (0.37) F10FPR2PLAUPLGITGB3
SCHEMBL17825459 0.92 PRCP (0.37) F10FPR2PLAUPLGITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107074820-B GLP-1 receptor modulators 赛尔基因第二国际有限公司 2021-05-18 — — CN disclosed
CN-112457301-A Novel GLP-1 receptor modulators 赛尔基因第二国际有限公司 2021-03-09 — — CN disclosed
US-9598430-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2017-03-21 — — US disclosed
US-20160214993-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-07-28 — — US disclosed
US-20160214993-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160214993-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R F10 1321/4885FPR2 492/4885ALDH1A1 4770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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