Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ADIPOR2 | Q86V24 | 1/20 | 0.52 |
| ▸ | ADIPOR1 | Q96A54 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | UBE2M | P61081 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17946000 | 0.87 | POLB (0.74) | POLBADIPOR2ADIPOR1USP2DRD4 | |
| SCHEMBL17950897 | 0.85 | POLB (0.62) | POLBADIPOR2ADIPOR1USP2DRD4 | |
| SCHEMBL17950916 | 0.83 | POLB (0.63) | POLBADIPOR2ADIPOR1USP2MCHR1 | |
| SCHEMBL17950881 | 0.83 | KMT2A (0.62) | POLBADIPOR2ADIPOR1USP2DRD4 | |
| SCHEMBL17950910 | 0.82 | USP2 (0.77) | POLBADIPOR2ADIPOR1USP2DRD4 | |
| SCHEMBL17946122 | 0.79 | ACKR3 (0.49) | POLBADIPOR2ADIPOR1USP2DRD4 | |
| SCHEMBL17950890 | 0.76 | SIGMAR1 (0.61) | POLBADIPOR2ADIPOR1USP2MCHR1 | |
| SCHEMBL17946047 | 0.75 | POLB (0.91) | POLBADIPOR2ADIPOR1USP2MCHR1 | |
| SCHEMBL25568935 | 0.71 | POLB (0.74) | POLBADIPOR2ADIPOR1USP2DRD4 | |
| SCHEMBL24514563 | 0.71 | POLB (0.86) | POLBADIPOR2ADIPOR1USP2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298051-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | THE UNIVERSITY OF TOKYO (JP) | 2017-10-19 | — | — | US | disclosed |
| US-20170298051-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | THE UNIVERSITY OF TOKYO (JP) | 2017-10-19 | — | — | US | disclosed |
| EP-3053911-A1 | ADIPONECTIN RECEPTOR-ACTIVATING COMPOUND | The University of Tokyo (JP) | 2016-08-10 | — | — | EP | disclosed |
| US-20160214967-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | THE UNIVERSITY OF TOKYO (JP) | 2016-07-28 | — | — | US | disclosed |
| US-20160214967-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | THE UNIVERSITY OF TOKYO (JP) | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214967-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | ADIPOR1, ADIPOR2, CCKAR | POLB 4574/4885ADIPOR2 2/4885ADIPOR1 1/4885 |
| US-20170298051-A1 | ACTIVATOR OF ADIPONECTIN RECEPTOR | ADIPOR1, ADIPOR2, CCKAR | POLB 4574/4885ADIPOR2 2/4885ADIPOR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.