Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10948259 | 0.73 | BACE1 (0.43) | PRMT5WDR77EPHX2BACE1NOTUM | |
| SCHEMBL12326069 | 0.72 | PRMT5 (0.52) | PRMT5WDR77EPHX2BACE1NOTUM | |
| SCHEMBL17950468 | 0.71 | PRMT5 (0.39) | PRMT5WDR77BACE1GAAHDAC4 | |
| SCHEMBL1841772 | 0.70 | PARP1 (0.54) | MAPT | |
| SCHEMBL874689 | 0.70 | PARP1 (0.54) | MAPT | |
| SCHEMBL874078 | 0.70 | PARP1 (0.54) | MAPTTDP1 | |
| SCHEMBL3262503 | 0.70 | PIM1 (0.54) | PRMT5WDR77GAAMAPTKMT2A | |
| SCHEMBL38660888 | 0.70 | GPR3 (0.47) | PRMT5WDR77BACE1KMT2ATDP1 | |
| SCHEMBL23087410 | 0.70 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL11120063 | 0.69 | IP6K1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016116058-A1 | TRIAZINE HETEROCYCLIC COMPOUND WITH NEMATICIDAL ACTIVITY AND PREPARATION METHOD THEREFOR AND USAGE THEREOF | 华东理工大学 | 2016-07-28 | — | — | WO | disclosed |