Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798244 | 0.85 | GRM5 (0.60) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL1795461 | 0.81 | NPC1 (0.52) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL1797024 | 0.78 | GRM5 (0.54) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL1033594 | 0.76 | MAPT (0.62) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL15626320 | 0.76 | CYP3A4 (0.57) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL4777225 | 0.75 | KMO (0.60) | KDM4EKMT2ALMNAHTT | |
| SCHEMBL1795424 | 0.74 | NPC1 (0.70) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL18997302 | 0.74 | ALDH1A1 (0.72) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL1491005 | 0.74 | GRM5 (1.00) | GRM5 | |
| SCHEMBL1794711 | 0.74 | GRM5 (0.49) | GRM5KDM4ENPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |