Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792734 | 0.88 | GRM5 (0.48) | GRM5DYRK1APDE10A | |
| SCHEMBL1794925 | 0.87 | POLQ (0.41) | GRM5CYP1A2CYP2C9DYRK1ACYP3A4 | |
| SCHEMBL1794208 | 0.84 | GRM5 (0.42) | GRM5 | |
| SCHEMBL1793989 | 0.83 | MEN1 (0.46) | GRM5 | |
| SCHEMBL1796910 | 0.82 | GRM5 (0.52) | GRM5CYP3A4DRD3SLC6A3 | |
| SCHEMBL1794339 | 0.81 | GRM5 (0.45) | GRM5 | |
| SCHEMBL1795689 | 0.80 | POLQ (0.42) | GRM5 | |
| SCHEMBL1793726 | 0.79 | GRM5 (0.40) | GRM5 | |
| SCHEMBL1798486 | 0.78 | SMN1; SMN2 (0.47) | GRM5 | |
| SCHEMBL1793688 | 0.77 | POLQ (0.38) | GRM5GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |