Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 3/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | RORB | Q92753 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796425 | 0.84 | SMARCA2 (0.57) | POLQSMARCA2SMARCA4GRM5MEN1 | |
| SCHEMBL1798486 | 0.83 | SMN1; SMN2 (0.47) | GRM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL1792734 | 0.82 | GRM5 (0.48) | POLQGRM5KMT2AKDM4E | |
| SCHEMBL1794339 | 0.82 | GRM5 (0.45) | POLQGRM5MEN1NPC1RAB9A | |
| SCHEMBL1794079 | 0.81 | GRM5 (0.47) | POLQSMARCA2SMARCA4GRM5TLR7 | |
| SCHEMBL1793989 | 0.81 | MEN1 (0.46) | POLQGRM5MEN1NPC1RAB9A | |
| SCHEMBL1795358 | 0.81 | GRM5 (0.52) | POLQGRM5NPC1RAB9AKDM4E | |
| SCHEMBL1795367 | 0.80 | GRM5 (0.36) | GRM5 | |
| SCHEMBL1794208 | 0.80 | GRM5 (0.42) | POLQGRM5MEN1NPC1RAB9A | |
| SCHEMBL4772430 | 0.78 | PARP10 (0.42) | POLQSMARCA2SMARCA4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |