Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPA | Q15257 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794339 | 0.91 | GRM5 (0.45) | SMN1; SMN2GRM5NPC1RAB9AKDM4E | |
| SCHEMBL1793989 | 0.86 | MEN1 (0.46) | GRM5NPC1RAB9AMAPTMEN1 | |
| SCHEMBL1797599 | 0.84 | ABL1 (0.53) | SMN1; SMN2ABL1GRM5ALDH1A1NPC1 | |
| SCHEMBL1795689 | 0.83 | POLQ (0.42) | GRM5NPC1RAB9AKDM4ETLR7 | |
| SCHEMBL1794208 | 0.83 | GRM5 (0.42) | SMN1; SMN2GRM5NPC1RAB9AKDM4E | |
| SCHEMBL1798409 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2ABL1GRM5ALDH1A1PTPRC | |
| SCHEMBL1794925 | 0.79 | POLQ (0.41) | GRM5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1795367 | 0.78 | GRM5 (0.36) | GRM5 | |
| SCHEMBL1795182 | 0.78 | GRM5 (0.50) | SMN1; SMN2GRM5NPC1RAB9AKDM4E | |
| SCHEMBL1792734 | 0.78 | GRM5 (0.48) | GRM5ALDH1A1KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |