Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.50 |
| ▸ | NNMT | P40261 | 5/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30296534 | 0.84 | SIRT6 (0.43) | SIRT6NNMTPOLBALDH1A1KDM4E | |
| SCHEMBL17325904 | 0.83 | NPSR1 (0.45) | SIRT6ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL30630664 | 0.83 | NPSR1 (0.45) | SIRT6ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL15995001 | 0.81 | NNMT (0.53) | SIRT6NNMTMKNK1MKNK2POLB | |
| SCHEMBL17325906 | 0.81 | SIRT6 (0.51) | SIRT6NNMTMKNK1MKNK2POLB | |
| SCHEMBL28642566 | 0.81 | SIRT6 (0.51) | SIRT6NNMTMKNK1MKNK2POLB | |
| SCHEMBL30296545 | 0.78 | SIRT6 (0.35) | SIRT6NNMTALDH1A1KDM4EMEN1 | |
| SCHEMBL28644569 | 0.77 | SIRT6 (0.51) | SIRT6NNMTMKNK1MKNK2POLB | |
| SCHEMBL19754916 | 0.77 | POLB (0.50) | SIRT6NNMTPOLBALDH1A1JAK2 | |
| SCHEMBL29829126 | 0.76 | SIRT6 (0.48) | SIRT6NNMTPOLBIKBKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016118404-A1 | IMINOTHIADIAZINE DIOXIDES BEARING AN AMINE-LINKED SUBSTITUENT AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2016-07-28 | — | — | WO | disclosed |