Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 6/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798156 | 0.89 | CYP1A2 (0.48) | SMARCA2SMARCA4GRM5HDAC4CYP1A2 | |
| SCHEMBL1794228 | 0.88 | SMARCA2 (0.58) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1797222 | 0.87 | SMARCA2 (0.49) | SMARCA2SMARCA4GRM5CYP1A2CYP3A4 | |
| SCHEMBL1794469 | 0.86 | SMARCA2 (0.56) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1796453 | 0.85 | SMARCA2 (0.61) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1798756 | 0.83 | GRM5 (0.54) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1792980 | 0.82 | GRM5 (0.58) | SMARCA2SMARCA4GRM5HDAC4CYP1A2 | |
| SCHEMBL1797503 | 0.81 | SMARCA2 (0.60) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1793853 | 0.80 | CYP1A2 (0.50) | SMARCA2SMARCA4GRM5HDAC4SORT1 | |
| SCHEMBL1797439 | 0.80 | SMARCA2 (0.49) | SMARCA2SMARCA4GRM5HDAC4SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |