Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 3/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.49 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | BCR | P11274 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798177 | 0.91 | GRM5 (0.53) | SMARCA2SMARCA4PORCNIRAK4ABL1 | |
| SCHEMBL1794228 | 0.88 | SMARCA2 (0.58) | SMARCA2SMARCA4GRM5 | |
| SCHEMBL1795623 | 0.87 | SMARCA2 (0.49) | SMARCA2SMARCA4GRM5CYP1A2CYP3A4 | |
| SCHEMBL1794469 | 0.86 | SMARCA2 (0.56) | SMARCA2SMARCA4GRM5 | |
| SCHEMBL1796453 | 0.85 | SMARCA2 (0.61) | SMARCA2SMARCA4PORCNGRM5 | |
| SCHEMBL1798156 | 0.85 | CYP1A2 (0.48) | SMARCA2SMARCA4GRM5CYP1A2CYP3A4 | |
| SCHEMBL1798756 | 0.83 | GRM5 (0.54) | SMARCA2SMARCA4GRM5CYP1A2CYP3A4 | |
| SCHEMBL1792980 | 0.82 | GRM5 (0.58) | SMARCA2SMARCA4PPARGGRM5CYP1A2 | |
| SCHEMBL1797503 | 0.81 | SMARCA2 (0.60) | SMARCA2SMARCA4PORCNGRM5MEN1 | |
| SCHEMBL1794792 | 0.81 | GRM5 (0.50) | PPARGGRM5CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |