Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 5/20 | 0.36 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 5/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17974176 | 0.87 | PPARA (0.36) | SLC6A4BACE1CTSDPPARAPPARD | |
| SCHEMBL17959922 | 0.79 | PDE2A (0.30) | — | |
| SCHEMBL17959881 | 0.79 | SLC6A4 (0.34) | SLC6A4 | |
| SCHEMBL17959929 | 0.78 | CHRM5 (0.37) | ABL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17107598 | 0.74 | PSEN1 (0.49) | SLC6A4BACE1CTSDPPARAPPARD | |
| SCHEMBL17107477 | 0.67 | PSEN1 (0.49) | SLC6A4BACE1CTSDPPARAPPARD | |
| SCHEMBL17107509 | 0.67 | PSEN1 (0.49) | SLC6A4BACE1CTSDPPARAPPARD | |
| SCHEMBL17966761 | 0.67 | BACE1 (0.37) | SLC6A4BACE1CTSDABL1KDM1A | |
| SCHEMBL17974179 | 0.66 | CCR6 (0.30) | — | |
| SCHEMBL8802196 | 0.64 | HIF1A (0.43) | CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253755-B1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3253755-B1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER (US) | 2020-08-26 | — | — | EP | disclosed |
| CN-107406445-B | Cyclopropylbenzofuranyl pyridopyrazine diones | 辉瑞公司 | 2019-12-24 | — | — | CN | disclosed |
| US-9765073-B2 | Cyclopropabenzofuranyl pyridopyrazinediones | PFIZER INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765073-B2 | Cyclopropabenzofuranyl pyridopyrazinediones | PFIZER INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765073-B2 | Cyclopropabenzofuranyl pyridopyrazinediones | PFIZER INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER INC. | 2017-04-06 | — | — | US | disclosed |
| WO-2016125048-A1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER INC. (US) | 2016-08-11 | — | — | WO | disclosed |
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER (US) | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | CYP4B1, RXRB, ADRA2B | SLC6A4 2629/4885BACE1 2997/4885CTSD 3024/4885 |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | CYP4B1, RXRB, ADRA2B | SLC6A4 2629/4885BACE1 2997/4885CTSD 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.