Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 11/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201705 | 0.81 | CA12 (0.36) | HIF1AEPAS1CA12CA9MAPT | |
| SCHEMBL2009830 | 0.81 | HIF1A (0.52) | HIF1AEPAS1CA12CA9COXFA4 | |
| SCHEMBL4017638 | 0.78 | HIF1A (0.42) | HIF1AEPAS1CA12CA9COXFA4 | |
| SCHEMBL6937184 | 0.78 | KCNE1 (0.45) | HIF1AEPAS1COXFA4PTGS1PTGS2 | |
| SCHEMBL4492932 | 0.76 | ALDH1A1 (0.51) | HIF1AEPAS1CA12CA9COXFA4 | |
| SCHEMBL7636259 | 0.75 | PTGS1 (0.45) | CA12CA9ALDH1A1HPGDMAPT | |
| SCHEMBL7301080 | 0.75 | PTGS1 (0.39) | CA12CA9PTGS1PTGS2CYP3A4 | |
| SCHEMBL6935054 | 0.75 | HIF1A (0.43) | HIF1AEPAS1CA12CA9COXFA4 | |
| SCHEMBL6024450 | 0.74 | HTR2C (0.54) | HIF1AEPAS1CA12CA9ALDH1A1 | |
| SCHEMBL8795292 | 0.73 | ALDH1A1 (0.40) | HIF1AEPAS1CA12CA9COXFA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566567-B1 | ANTIHYPERTENSIVE BENZOPYRAN DERIVATIVES | AMERICAN HOME PROD (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0350805-B1 | Benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds | BEIERSDORF LILLY GMBH (DE) | 1997-04-16 | — | — | EP | disclosed |
| EP-0566567-A1 | ANTIHYPERTENSIVE BENZOPYRAN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-27 | — | — | EP | disclosed |
| US-5252597-A | Antihypertensive benzopyran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0314446-B1 | NOVEL ANTIHYPERTENSIVE BENZOPYRAN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5171857-A | Antihypertensive benzopyran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-15 | — | — | US | disclosed |
| WO-1992020672-A1 | ISOINDOLYL AND ISOCHINOLYL-SUBSTITUTED BENZOPYRANE DERIVATIVES, INTERMEDIATE PRODUCTS, AND PROCESS FOR PRODUCING THEM | BEIERSDORF-LILLY GMBH (DE) | 1992-11-26 | — | — | WO | disclosed |
| WO-1992012153-A1 | NOVEL ANTIHYPERTENSIVE BENZOPYRAN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-23 | — | — | WO | disclosed |
| US-5096914-A | Hypotensive agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1992-03-17 | — | — | US | disclosed |
| US-5047552-A | Process for preparing benzopyran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-09-10 | — | — | US | disclosed |
| US-5028711-A | Hypotensive Agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1991-07-02 | — | — | US | disclosed |
| US-5021418-A | Antihypertensive benzopyran compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| US-4983612-A | Antihypertensive benzopyran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |
| US-4925839-A | Novel antihypertensive benzopyran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
| EP-0350805-A1 | Benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds | Beiersdorf-Lilly GmbH (DE) | 1990-01-17 | — | — | EP | disclosed |
| EP-0314446-A2 | Novel antihypertensive benzopyran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-05-03 | — | — | EP | disclosed |