Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17973311 | 1.00 | ALDH1A1 (0.36) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768601 | 1.00 | ALDH1A1 (0.36) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768587 | 0.77 | LMNA (0.36) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768603 | 0.77 | LMNA (0.36) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768617 | 0.77 | LMNA (0.36) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL17964324 | 0.71 | ALDH1A1 (0.31) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL17972845 | 0.71 | ALDH1A1 (0.31) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768614 | 0.71 | ALDH1A1 (0.31) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768569 | 0.71 | LMNA (0.33) | ALDH1A1USP2LMNAMAPTHSD17B10 | |
| SCHEMBL19768607 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250559-A1 | SPIROFURANONE COMPOUNDS, DERIVATIVES THEREOF AND PROCESSES FOR THEIR PREPARATION | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2017-12-06 | — | — | EP | disclosed |
| WO-2016120879-A1 | SPIROFURANONE COMPOUNDS, DERIVATIVES THEREOF AND PROCESSES FOR THEIR PREPARATION | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2016-08-04 | — | — | WO | disclosed |