Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798244 | 0.87 | GRM5 (0.60) | GRM5MAPTKDM4EALDH1A1RECQL | |
| SCHEMBL1794131 | 0.85 | GRM5 (0.50) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL1794711 | 0.84 | GRM5 (0.49) | GRM5MAPTKDM4EALDH1A1RECQL | |
| SCHEMBL1794106 | 0.83 | GRM5 (0.54) | GRM5NPC1RAB9A | |
| SCHEMBL1794965 | 0.83 | GRM5 (0.50) | GRM5KDM4ENPC1RAB9AGAA | |
| SCHEMBL1796217 | 0.78 | IRAK4 (0.47) | GRM5MAPTKDM4ENPC1RAB9A | |
| SCHEMBL1797179 | 0.77 | GRM5 (0.56) | GRM5KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1795189 | 0.74 | GRM5 (0.60) | GRM5 | |
| SCHEMBL1797792 | 0.74 | GRM5 (0.57) | GRM5MAPTKDM4ENPC1RAB9A | |
| SCHEMBL1795201 | 0.74 | GRM5 (0.59) | GRM5MAPTKDM4EALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |