Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.56 |
| ▸ | GRM5 | P41594 | 6/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795107 | 0.89 | GRM5 (0.70) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL7910106 | 0.86 | GRM5 (0.59) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL7898444 | 0.81 | GRM5 (0.54) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL13148087 | 0.81 | GRM5 (0.51) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL1797770 | 0.78 | SORT1 (0.58) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL1795941 | 0.77 | CYP3A4 (0.63) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL7904772 | 0.77 | GRM5 (0.46) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL1794792 | 0.77 | GRM5 (0.50) | GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL7910110 | 0.76 | GRM5 (0.72) | SORT1GRM5CYP1A2CYP2C9KMT2A | |
| SCHEMBL15891245 | 0.75 | CYP1A2 (0.62) | GRM5CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |