Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795189 | 0.91 | GRM5 (0.60) | GRM5CYP1A2CYP2C9 | |
| SCHEMBL1793909 | 0.84 | KMT2A (0.53) | GRM5KMT2ACYP1A2CYP2C9IDE | |
| SCHEMBL1796059 | 0.83 | SMN1; SMN2 (0.58) | KMT2ACYP1A2CYP2C9PPARGTDP1 | |
| SCHEMBL1796217 | 0.81 | IRAK4 (0.47) | GRM5 | |
| SCHEMBL1797222 | 0.81 | SMARCA2 (0.49) | GRM5KMT2ACYP1A2CYP2C9PPARG | |
| SCHEMBL1795519 | 0.80 | NPC1 (0.47) | GRM5KMT2AIDE | |
| SCHEMBL7910106 | 0.79 | GRM5 (0.59) | GRM5KMT2ACYP1A2CYP2C9 | |
| SCHEMBL1798177 | 0.78 | GRM5 (0.53) | GRM5PPARG | |
| SCHEMBL1798244 | 0.77 | GRM5 (0.60) | GRM5KMT2A | |
| SCHEMBL1797017 | 0.77 | SORT1 (0.56) | GRM5KMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |