Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6355521 | 0.84 | KMT2A (0.62) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL10047880 | 0.80 | KMT2A (0.63) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL17165572 | 0.78 | KMT2A (0.56) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL17980841 | 0.77 | MAPT (0.56) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL10047911 | 0.76 | KMT2A (1.00) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL2685197 | 0.76 | ALDH1A1 (1.00) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL13969677 | 0.73 | KMT2A (0.50) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL19416378 | 0.72 | KMT2A (0.49) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL2684725 | 0.72 | KMT2A (0.53) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL21632834 | 0.72 | KMT2A (0.68) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691997-B2 | Macrocycles | LUMIPHORE, INC. (US) | 2023-07-04 | — | — | US | disclosed |
| US-20170183365-A1 | MACROCYCLES | LUMIPHORE, INC. | 2017-06-29 | — | — | US | disclosed |
| US-20160221971-A1 | DI-MACROCYCLES | LUMIPHORE, INC. (US) | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221971-A1 | DI-MACROCYCLES | DLD, NDC1, MCL1 | MAPT 1196/4885KMT2A 4469/4885ALDH1A1 1827/4885 |
| US-11691997-B2 | Macrocycles | HCCS, ABCB7, AURKAIP1 | MAPT 1131/4885KMT2A 4535/4885ALDH1A1 1863/4885 |
| US-20170183365-A1 | MACROCYCLES | HCCS, ABCB7, AURKAIP1 | MAPT 1131/4885KMT2A 4535/4885ALDH1A1 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.