Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17974953 | 0.87 | CLEC4M (0.48) | CLEC4MCYP1A2CYP3A4CYP2C19GABRA1 | |
| SCHEMBL17974954 | 0.86 | ALDH1A1 (0.42) | CLEC4MCYP1A2CYP3A4CYP2C19JAK3 | |
| SCHEMBL17975182 | 0.80 | CLEC4M (0.40) | CLEC4MCYP1A2CYP3A4CYP2C19GABRA1 | |
| SCHEMBL17963325 | 0.78 | ALDH1A1 (0.33) | KMT2AALDH1A1 | |
| SCHEMBL23212216 | 0.77 | GABRA1 (0.38) | CLEC4MGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL17963447 | 0.77 | MAPT (0.45) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL15956965 | 0.74 | BRD4 (0.53) | BAZ2BBAZ2AKMT2AKDM4ENPSR1 | |
| SCHEMBL31348908 | 0.74 | KDM4E (0.56) | CLEC4MCYP1A2CYP3A4CYP2C19GABRA1 | |
| SCHEMBL11895681 | 0.73 | CLEC4M (0.53) | CLEC4MCYP1A2CYP3A4CYP2C19GABRA1 | |
| SCHEMBL2035901 | 0.72 | CLEC4M (0.55) | CLEC4MCYP1A2CYP3A4CYP2C19GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531692-B | Therapeutic compounds and uses thereof | 基因泰克公司 | 2020-12-25 | — | — | CN | disclosed |
| US-10202378-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| WO-2016123391-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202378-B2 | Therapeutic compounds and uses thereof | TAF1, TAF1L, TAF1B | CLEC4M 4872/4885CYP1A2 3656/4885CYP3A4 4039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.