Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.55 |
| ▸ | PNMT | P11086 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10560530 | 1.00 | SLC7A5 (0.55) | SLC7A5PNMTCTSLNOS3NOS1 | |
| SCHEMBL18481474 | 0.84 | SLC7A5 (0.56) | SLC7A5NOS3NOS1NOS2LTA4H | |
| SCHEMBL18788872 | 0.84 | SLC7A5 (0.56) | SLC7A5NOS3NOS1NOS2LTA4H | |
| SCHEMBL3028647 | 0.84 | SLC7A5 (0.56) | SLC7A5NOS3NOS1NOS2LTA4H | |
| SCHEMBL27525604 | 0.84 | SLC7A5 (0.56) | SLC7A5NOS3NOS1NOS2LTA4H | |
| SCHEMBL3698756 | 0.84 | SLC7A5 (0.51) | SLC7A5PNMTCTSLNOS3NOS1 | |
| SCHEMBL10886331 | 0.84 | SLC7A5 (0.51) | SLC7A5PNMTCTSLNOS3NOS1 | |
| SCHEMBL1519859 | 0.84 | SLC7A5 (0.51) | SLC7A5PNMTCTSLNOS3NOS1 | |
| SCHEMBL5222169 | 0.84 | PNMT (0.58) | SLC7A5PNMTNOS3NOS1NOS2 | |
| SCHEMBL8703262 | 0.84 | PNMT (0.58) | SLC7A5PNMTNOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111150851-A | Ligand-cytotoxic drug conjugate, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-106794258-B | Ligand-cytotoxic drug conjugate, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2019-07-12 | — | — | CN | disclosed |
| US-20180177890-A1 | LIGAND-CYTOTOXIC DRUG CONJUGATE, PREPARATION METHOD THEREOF, AND USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-06-28 | — | — | US | disclosed |
| EP-3251698-A1 | LIGAND-CYTOTOXICITY DRUG CONJUGATE, PREPARING METHOD THEREFOR, AND APPLICATION THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2017-12-06 | — | — | EP | disclosed |
| CN-106794258-A | Ligand-cytotoxic drug conjugate, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| WO-2016127790-A1 | LIGAND-CYTOTOXICITY DRUG CONJUGATE, PREPARING METHOD THEREFOR, AND APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2016-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180177890-A1 | LIGAND-CYTOTOXIC DRUG CONJUGATE, PREPARATION METHOD THEREOF, AND USE THEREOF | LDLR, SELPLG, FOLR1 | SLC7A5 1738/4885PNMT 2778/4885CTSL 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.