Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17980030 | 0.89 | GPR119 (0.42) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL17979997 | 0.89 | GPR119 (0.42) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL17980115 | 0.82 | GPR119 (0.43) | GPR119ALDH1A1MEN1KMT2ADPP4 | |
| SCHEMBL24080179 | 0.81 | GPR119 (0.41) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL28897864 | 0.81 | GPR119 (0.41) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL17979924 | 0.81 | GPR119 (0.41) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL18353813 | 0.79 | GPR119 (0.42) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL18022628 | 0.76 | APP (0.42) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL17980177 | 0.76 | ALDH1A1 (0.40) | GPR119ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL21081109 | 0.76 | GPR119 (0.40) | GPR119ALDH1A1APPHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256466-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | Sunovion Pharmaceuticals Inc. (US) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016130796-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2016-08-18 | — | — | WO | disclosed |