Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17979996 | 0.92 | ALOX5AP (0.47) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL12431647 | 0.88 | CHRNB4 (0.49) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL2199003 | 0.88 | CHRNB4 (0.49) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL17980174 | 0.87 | ALOX5AP (0.45) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL2259269 | 0.87 | ALOX5AP (0.49) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL17980114 | 0.86 | GPR119 (0.41) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL15500342 | 0.85 | ALOX5AP (0.46) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL17980065 | 0.84 | ALOX5AP (0.44) | ALOX5APFEN1APPHTR1AADRA2A | |
| SCHEMBL2200803 | 0.80 | ALOX5AP (0.50) | ALOX5APFEN1F2RL3 | |
| SCHEMBL2200755 | 0.79 | CHRNB4 (0.58) | ALOX5APFEN1F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256466-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | Sunovion Pharmaceuticals Inc. (US) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016130796-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2016-08-18 | — | — | WO | disclosed |