Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28797265 | 0.90 | CNR1 (0.41) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL15255041 | 0.86 | CNR1 (0.43) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL1760417 | 0.81 | CNR1 (0.50) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL30027246 | 0.81 | CNR1 (0.50) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL6232640 | 0.80 | CNR1 (0.39) | CNR1CNR2PRKCIKDM4EALDH1A1 | |
| SCHEMBL28871536 | 0.80 | CNR1 (0.39) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL9861540 | 0.78 | PRKCI (0.41) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL28417332 | 0.76 | DRD4 (0.39) | DRD4TSHR | |
| SCHEMBL6235059 | 0.75 | CNR1 (0.42) | CNR1CNR2CYP2D6DRD4PRKCI | |
| SCHEMBL31098402 | 0.74 | KDM4E (0.36) | DRD4HSD17B10KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951822-B2 | 1,3-dihydroisobenzofuran derivatives | KOWA COMPANY, LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-7951822-B2 | 1,3-dihydroisobenzofuran derivatives | KOWA COMPANY, LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-7951822-B2 | 1,3-dihydroisobenzofuran derivatives | KOWA COMPANY, LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| EP-2264029-A1 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-12-22 | — | — | EP | disclosed |
| EP-2264029-A1 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-12-22 | — | — | EP | disclosed |
| US-20090247587-A1 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVES | KOWA COMPANY, LTD. (JP) | 2009-10-01 | — | — | US | disclosed |
| US-20090247587-A1 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVES | KOWA COMPANY, LTD. (JP) | 2009-10-01 | — | — | US | disclosed |
| US-20090247587-A1 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVES | KOWA COMPANY, LTD. (JP) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247587-A1 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVES | SREBF1, NR1H2, LDLR | CNR1 726/4885CNR2 1087/4885CYP2D6 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.