Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | CPN1 | P15169 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.37 |
| ▸ | APLNR | P35414 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798175 | 1.00 | KDM4E (0.44) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL1801069 | 0.90 | KCNH2 (0.40) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL1801065 | 0.90 | KCNH2 (0.40) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6371477 | 0.85 | CPN1 (0.45) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL384884 | 0.85 | CPN1 (0.45) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL384885 | 0.85 | CPN1 (0.45) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL1802729 | 0.79 | EPHX1 (0.45) | KDM4EKMT2ATSHRNOS2KDM1A | |
| SCHEMBL1802725 | 0.79 | EPHX1 (0.45) | KDM4EKMT2ATSHRNOS2KDM1A | |
| SCHEMBL6314603 | 0.78 | EPHX1 (0.48) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL7619038 | 0.78 | EPHX1 (0.48) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |