Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801069 | 1.00 | KCNH2 (0.40) | KCNH2EPHX1KDM1AKDM4EMAPT | |
| SCHEMBL1798169 | 0.90 | KDM4E (0.44) | KCNH2KDM1AKDM4EMAPTKMT2A | |
| SCHEMBL1798175 | 0.90 | KDM4E (0.44) | KCNH2KDM1AKDM4EMAPTKMT2A | |
| SCHEMBL1802725 | 0.89 | EPHX1 (0.45) | EPHX1KDM1AKDM4EKMT2APOLB | |
| SCHEMBL1802729 | 0.89 | EPHX1 (0.45) | EPHX1KDM1AKDM4EKMT2APOLB | |
| SCHEMBL825689 | 0.84 | KCNH2 (0.41) | KCNH2EPHX1KDM1APOLBSLC6A1 | |
| SCHEMBL825809 | 0.84 | KCNH2 (0.41) | KCNH2EPHX1KDM1APOLBSLC6A1 | |
| SCHEMBL31109672 | 0.84 | KCNH2 (0.41) | KCNH2EPHX1KDM1APOLBSLC6A1 | |
| SCHEMBL2156251 | 0.78 | — | — | |
| SCHEMBL2156260 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |