Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17981985 | 0.77 | LOXL2 (0.48) | LOXL2NR3C2 | |
| SCHEMBL2170664 | 0.77 | AR (0.35) | TAAR1 | |
| SCHEMBL17981888 | 0.76 | AAK1 (0.32) | — | |
| SCHEMBL22383611 | 0.72 | HTT (0.46) | LOXL2 | |
| SCHEMBL17981995 | 0.72 | SCN9A (0.33) | SCN9ATRPA1LOXL2TGFBR1SREBF2 | |
| SCHEMBL19837735 | 0.72 | MAPK14 (0.34) | TGFBR1SREBF2MAP4K4MAPKAPK2 | |
| SCHEMBL18019672 | 0.72 | MAPK14 (0.34) | TGFBR1SREBF2MAP4K4MAPKAPK2 | |
| SCHEMBL19837736 | 0.72 | MAPK14 (0.34) | TGFBR1SREBF2MAP4K4MAPKAPK2 | |
| SCHEMBL17981980 | 0.72 | MAPK14 (0.34) | TGFBR1SREBF2MAP4K4MAPKAPK2 | |
| SCHEMBL17981865 | 0.71 | MAOB (0.53) | SCN9ALOXL2TGFBR1SREBF2NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016130396-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-08-18 | — | — | WO | disclosed |