Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20449206 | 0.79 | TRPA1 (0.38) | TRPA1LOXL2 | |
| SCHEMBL2170155 | 0.77 | AR (0.30) | — | |
| SCHEMBL2788936 | 0.77 | LOXL2 (0.40) | SCN9ATGFBR1LOXL2HTR1ADRD2 | |
| SCHEMBL17982022 | 0.77 | AAK1 (0.31) | — | |
| SCHEMBL17981871 | 0.74 | LOXL2 (0.45) | SCN9ATGFBR1LOXL2HTR1ADRD2 | |
| SCHEMBL17981982 | 0.72 | SCN9A (0.37) | SCN9ATGFBR1TRPA1LOXL2HTR1A | |
| SCHEMBL18019671 | 0.71 | KDM4C (0.40) | TGFBR1 | |
| SCHEMBL19837724 | 0.71 | KDM4C (0.40) | TGFBR1 | |
| SCHEMBL19853121 | 0.71 | KDM4C (0.40) | TGFBR1 | |
| SCHEMBL17981994 | 0.71 | KDM4C (0.40) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016130396-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-08-18 | — | — | WO | disclosed |