Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799494 | 0.91 | TNIK (0.39) | NTRK1HTR2CKITMAP3K11HPGD | |
| SCHEMBL1801258 | 0.90 | MAP3K11 (0.46) | NTRK1ROCK1MAP3K11WDR5 | |
| SCHEMBL1801878 | 0.84 | HTR2C (0.56) | NTRK1HTR2CKITPLK4JAK2 | |
| SCHEMBL1801625 | 0.84 | AXL (0.40) | NTRK1PLK4ROS1FGFR1FLT1 | |
| SCHEMBL1797469 | 0.82 | HTR2C (0.53) | NTRK1HTR2CKITPLK4JAK2 | |
| SCHEMBL1798275 | 0.81 | NTRK1 (0.47) | NTRK1HTR2CKITPLK4JAK2 | |
| SCHEMBL1799017 | 0.80 | NTRK1 (0.44) | NTRK1HTR2CKITPLK4JAK2 | |
| SCHEMBL1802608 | 0.78 | NTRK1 (0.45) | NTRK1HTR2CKITPLK4JAK2 | |
| SCHEMBL1801875 | 0.78 | HTR2C (0.48) | NTRK1HTR2CKITPLK4JAK2 | |
| SCHEMBL8442699 | 0.78 | HTR2C (0.48) | NTRK1HTR2CKITPLK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951802-B2 | Use of 7-azaindoles in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |