Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554345 | 0.87 | PARP14 (0.49) | TDP1ALDH1A1PARP1GPR3SLC9A1 | |
| SCHEMBL16919472 | 0.81 | CYP19A1 (0.43) | TDP1ALDH1A1PARP1GPR3CYP19A1 | |
| SCHEMBL15139099 | 0.81 | ALDH1A1 (0.44) | TDP1ALDH1A1PARP1GPR3SLC9A1 | |
| SCHEMBL16919494 | 0.80 | PARP14 (0.43) | TDP1ALDH1A1PARP1GPR3CYP19A1 | |
| SCHEMBL23457352 | 0.80 | PARP14 (0.46) | TDP1ALDH1A1PARP1SLC9A1MAPT | |
| SCHEMBL19961730 | 0.79 | ALDH1A1 (0.42) | TDP1ALDH1A1PARP1SLC9A1CYP19A1 | |
| SCHEMBL15318845 | 0.79 | POLB (0.47) | TDP1ALDH1A1CYP19A1NPC1MAPT | |
| SCHEMBL3293386 | 0.79 | TDP1 (0.53) | TDP1ALDH1A1PARP1GPR3SLC9A1 | |
| SCHEMBL31478092 | 0.79 | TDP1 (0.53) | TDP1ALDH1A1PARP1GPR3SLC9A1 | |
| SCHEMBL16218716 | 0.77 | ALDH1A1 (0.46) | TDP1ALDH1A1CYP19A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-08-18 | — | — | US | disclosed |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-08-18 | — | — | US | disclosed |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNB2, CHRNB3 | TDP1 860/4885ALDH1A1 1229/4885PARP1 4543/4885 |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNB2, CHRNB3 | TDP1 860/4885ALDH1A1 1229/4885PARP1 4543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.