Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 12/20 | 0.46 |
| ▸ | CTSC | P53634 | 5/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16647963 | 0.86 | TRPA1 (0.61) | TRPA1PTGES | |
| Hydrochloric Acid SCHEMBL16635010 | 0.86 | TRPA1 (0.60) | TRPA1PTGES | |
| SCHEMBL16634879 | 0.84 | TRPA1 (0.58) | TRPA1PTGES | |
| SCHEMBL17987069 | 0.81 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL16648008 | 0.79 | TRPA1 (0.59) | TRPA1PTGES | |
| Hydrochloric Acid SCHEMBL17959555 | 0.79 | TRPA1 (0.58) | TRPA1PTGES | |
| SCHEMBL16635721 | 0.77 | CTSC (0.38) | TRPA1CTSCHTR2CMASP2 | |
| SCHEMBL16648080 | 0.76 | TRPA1 (0.62) | TRPA1PTGES | |
| SCHEMBL16635288 | 0.76 | CTSC (0.41) | CTSCHTR2CMASP2 | |
| Hydrochloric Acid SCHEMBL17959542 | 0.76 | TRPA1 (0.61) | TRPA1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160221945-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | GENENTECH, INC. (US) | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221945-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885CTSC 1795/4885PTGES 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.