Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17987872 | 0.89 | NPC1 (0.57) | NPC1MAPTRAB9AOPRK1KMT2A | |
| SCHEMBL17987860 | 0.86 | HSP90AA1 (0.54) | NPC1MAPTRAB9AOPRK1KMT2A | |
| SCHEMBL17987882 | 0.85 | SCD (0.61) | NPC1MAPTRAB9AOPRK1KMT2A | |
| SCHEMBL17987883 | 0.81 | HSP90AA1 (0.50) | NPC1MAPTRAB9AOPRK1KMT2A | |
| SCHEMBL17987822 | 0.80 | MAOA (0.48) | NPC1MAPTRAB9AOPRK1KMT2A | |
| SCHEMBL17985741 | 0.79 | RAB9A (0.65) | NPC1MAPTRAB9AOPRK1KMT2A | |
| SCHEMBL17985747 | 0.78 | HSP90AA1 (0.76) | NPC1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL17987823 | 0.78 | HSP90AA1 (0.54) | NPC1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL17987878 | 0.77 | HSP90AA1 (0.55) | NPC1RAB9APKMHSP90AA1MAOA | |
| SCHEMBL17987889 | 0.76 | HSP90AA1 (0.54) | NPC1MAPTRAB9AOPRK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828288-B2 | Hydrazone derivatives for the treatment of cancer | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-11-10 | — | — | US | disclosed |
| WO-2016123253-A1 | HYDRAZNE DERIVATIVES FOR THE TREATMENT OF CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828288-B2 | Hydrazone derivatives for the treatment of cancer | H1-3, H1-5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | NPC1 2134/4885MAPT 4822/4885RAB9A 2175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.