Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.50 |
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | ADAM10 | O14672 | 4/20 | 0.50 |
| ▸ | MMP9 | P14780 | 4/20 | 0.50 |
| ▸ | MMP14 | P50281 | 4/20 | 0.50 |
| ▸ | ADAM8 | P78325 | 3/20 | 0.50 |
| ▸ | MMP12 | P39900 | 2/20 | 0.50 |
| ▸ | BMP1 | P13497 | 11/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.44 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800831 | 0.91 | ADAM17 (0.50) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL1798723 | 0.86 | ADAM17 (0.49) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL4372650 | 0.82 | BMP1 (0.51) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL4375790 | 0.82 | ADAM17 (0.49) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL1800584 | 0.82 | ADAM17 (0.49) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL1799177 | 0.81 | BMP1 (0.58) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL4377322 | 0.80 | ADAM17 (0.56) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL1798846 | 0.78 | DAGLA (0.38) | MMP2MMP14ADAMTS4MMP1ADAMTS5 | |
| SCHEMBL3940072 | 0.75 | ADAM17 (0.62) | ADAM17MMP2ADAM10MMP9MMP14 | |
| SCHEMBL3945454 | 0.75 | ADAM17 (0.62) | ADAM17MMP2ADAM10MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1461313-A1 | HUMAN ADAM-10 INHIBITORS | Exelixis, Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003051825-A1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS, INC. (US) | 2003-06-26 | — | — | WO | disclosed |