Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288006 | 0.86 | GPR119 (0.41) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14791637 | 0.86 | GPR119 (0.41) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL288005 | 0.86 | GPR119 (0.41) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL10214995 | 0.86 | GPR119 (0.41) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL11993158 | 0.84 | GPR119 (0.41) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14706990 | 0.82 | GPR119 (0.39) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13175831 | 0.82 | PDE4B (0.39) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13163063 | 0.81 | CHRNB2 (0.41) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14709891 | 0.79 | CHRNB2 (0.43) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL10139547 | 0.79 | CHRNB2 (0.50) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409918-B2 | Bridged bicyclic piperidine derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2016-08-09 | — | — | US | disclosed |