Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478984 | 0.83 | PTK2 (0.49) | JAK2PTK2JAK3FGFR1LCK | |
| SCHEMBL12478815 | 0.81 | ALK (0.55) | JAK2PTK2JAK3ALKFGFR1 | |
| SCHEMBL14643155 | 0.80 | SYK (0.47) | JAK2PTK2JAK3ALKFGFR1 | |
| SCHEMBL15568488 | 0.80 | PTK2 (0.78) | PTK2 | |
| SCHEMBL15568490 | 0.80 | PTK2 (0.49) | PTK2JAK3LCKCDK4CCND1 | |
| SCHEMBL29520512 | 0.78 | BRD4 (0.65) | PTK2ALKLCKCDK4CCND1 | |
| SCHEMBL29037695 | 0.78 | BRD4 (0.65) | PTK2ALKLCKCDK4CCND1 | |
| SCHEMBL24731745 | 0.78 | JAK3 (0.55) | JAK2JAK3ALKFGFR1CDK4 | |
| SCHEMBL12478994 | 0.78 | CCND3 (0.63) | JAK2PTK2JAK3ALKCDK4 | |
| SCHEMBL29989713 | 0.77 | JAK2 (0.61) | JAK2FGFR1SYKBRD4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9421205-B2 | FAK inhibitors | Cancer Therapeutics CRC Pty Ltd. (AU) | 2016-08-23 | — | — | US | disclosed |