Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469483 | 0.81 | KDM4E (0.72) | KDM4EL3MBTL1ALDH1A1ADORA3ADORA2A | |
| SCHEMBL28182135 | 0.79 | KDM4E (0.47) | KDM4EL3MBTL1KDM5AALDH1A1ADORA3 | |
| SCHEMBL18717442 | 0.79 | F11 (0.47) | KDM4EMAPK1FASN | |
| SCHEMBL15113447 | 0.75 | KDM4E (0.36) | KDM4ECYP2C9 | |
| SCHEMBL21773988 | 0.71 | ERBB2 (0.46) | KDM4EL3MBTL1KDM5AALDH1A1ADORA2A | |
| SCHEMBL13847513 | 0.68 | KDM4E (0.69) | KDM4EL3MBTL1ALDH1A1ADORA3ADORA2A | |
| SCHEMBL12960720 | 0.67 | KDM4E (0.57) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL2756747 | 0.67 | CYP1A2 (0.58) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL10861808 | 0.66 | KDM4E (0.34) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL11965492 | 0.66 | NISCH (0.40) | KDM4EL3MBTL1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229839-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229839-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | KDM4E 454/4885L3MBTL1 4356/4885KDM5A 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.