Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17996561 | 0.87 | PDE2A (0.50) | PDE2AALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL1721415 | 0.82 | PDE2A (0.51) | PDE2AALDH1A1CYP17A1CYP2C9CYP2C19 | |
| SCHEMBL28615738 | 0.82 | PDE2A (0.51) | PDE2AALDH1A1CYP17A1CYP2C9CYP2C19 | |
| SCHEMBL5698984 | 0.79 | SCN9A (0.49) | PDE2AALDH1A1TOP2ATOP2BSCN9A | |
| SCHEMBL5698985 | 0.79 | SCN9A (0.49) | PDE2AALDH1A1TOP2ATOP2BSCN9A | |
| SCHEMBL18291828 | 0.78 | PDE2A (0.54) | PDE2AALDH1A1EPHX1TOP2ATOP2B | |
| SCHEMBL1046494 | 0.78 | PDE2A (0.54) | PDE2AALDH1A1EPHX1TOP2ATOP2B | |
| SCHEMBL17996515 | 0.78 | UGCG (0.52) | ALDH1A1CYP2C19HRH3LMNA | |
| SCHEMBL18101801 | 0.78 | MEN1 (0.40) | CYP17A1CYP2C9CYP2C19LMNA | |
| SCHEMBL28729244 | 0.75 | PDE2A (0.42) | PDE2AALDH1A1LMNAMAPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229830-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229830-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | GBA1, UGCG, GBA2 | PDE2A 594/4885ALDH1A1 1342/4885NOS3 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.