Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801153 | 0.91 | HDAC1 (0.47) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL1798901 | 0.82 | HDAC1 (0.52) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL1799805 | 0.81 | HDAC1 (0.51) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL28958714 | 0.79 | AOC3 (0.41) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL28958712 | 0.79 | AOC3 (0.41) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL8127646 | 0.79 | HDAC1 (0.53) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL24323598 | 0.78 | BACE1 (0.62) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL29059512 | 0.78 | BACE1 (0.62) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL24324611 | 0.77 | HDAC3 (0.52) | HDAC1HDAC3HDAC2NCOR2BACE1 | |
| SCHEMBL15311357 | 0.77 | HDAC3 (0.52) | HDAC1HDAC3HDAC2NCOR2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951954-B2 | Bezothiazol derivatives as Beta2 adrenoreceptor agonists | ASTRAZENECA AB (SE) | 2011-05-31 | — | — | US | disclosed |
| CN-101443320-A | Benzothiazole derivatives as beta 2 adrenoreceptor agonists | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| US-20090062259-A1 | Bezothiazol Derivatives as Beta2 Adrenoreceptor Agonists | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062259-A1 | Bezothiazol Derivatives as Beta2 Adrenoreceptor Agonists | ADRB2, ADRB1, ADRB3 | HDAC1 611/4885HDAC3 562/4885HDAC2 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.