Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708343 | 0.96 | POLB (0.58) | POLBSMN1; SMN2MAPTGBA1ALDH1A1 | |
| SCHEMBL17066352 | 0.85 | HTR3A (0.54) | POLBSMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL29732670 | 0.85 | POLB (0.55) | POLBSMN1; SMN2MAPTGBA1ALDH1A1 | |
| SCHEMBL9486237 | 0.83 | ALDH1A1 (0.54) | POLBSMN1; SMN2ALDH1A1MAPK1USP2 | |
| SCHEMBL17531186 | 0.83 | KDM4E (0.54) | POLBALDH1A1MAPK1USP2CYP1A2 | |
| Hydrochloric Acid SCHEMBL8579574 | 0.82 | ALDH1A1 (0.52) | POLBSMN1; SMN2ALDH1A1MAPK1USP2 | |
| Hydrochloric Acid SCHEMBL10410648 | 0.82 | ALDH1A1 (0.52) | POLBSMN1; SMN2ALDH1A1MAPK1USP2 | |
| SCHEMBL29732880 | 0.81 | ALDH1A1 (0.51) | POLBSMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL26975238 | 0.81 | POLB (0.44) | POLBSMN1; SMN2GBA1ALDH1A1MAPK1 | |
| SCHEMBL14983697 | 0.80 | POLB (0.44) | POLBSMN1; SMN2MAPTGBA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016133959-A9 | THERAPEUTIC COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2018-02-22 | — | — | WO | disclosed |
| EP-3259254-A1 | THERAPEUTIC COMPOUNDS | Arizona Board of Regents on behalf of Arizona State University (US) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016133959-A1 | THERAPEUTIC COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2016-08-25 | — | — | WO | disclosed |