Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.47 |
| ▸ | TACR1 | P25103 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675366 | 0.82 | KIF11 (0.50) | KIF11TACR1FFAR1FFAR4BACE1 | |
| SCHEMBL13872997 | 0.82 | PTGS2 (0.43) | FFAR1FFAR4SLC6A4SLC6A3RIPK1 | |
| SCHEMBL5336630 | 0.81 | DPP4 (0.54) | TACR1ALDH1A1SLC6A2HSD17B10RIPK1 | |
| SCHEMBL5198493 | 0.80 | PDK2 (0.53) | KIF11TACR1FFAR1FFAR4BACE1 | |
| SCHEMBL5199432 | 0.79 | KIF11 (0.50) | KIF11TACR1FFAR1FFAR4BACE1 | |
| SCHEMBL22548896 | 0.79 | KCNA5 (0.46) | KIF11ALDH1A1TSHRHSD17B10RIPK1 | |
| SCHEMBL5511135 | 0.79 | KIF11 (0.50) | KIF11TACR1FFAR1FFAR4BACE1 | |
| SCHEMBL18014704 | 0.79 | CYP2C19 (0.44) | FFAR1FFAR4ALDH1A1TSHRSLC6A2 | |
| SCHEMBL9295043 | 0.79 | DPP4 (0.62) | KIF11TACR1FFAR1FFAR4BACE1 | |
| SCHEMBL2096005 | 0.79 | KIF11 (0.50) | KIF11TACR1FFAR1FFAR4BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | KIF11 4539/4885TACR1 1388/4885FFAR1 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.