Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 10/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12002675 | 0.89 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL19933574 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL1416706 | 0.82 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL27618211 | 0.81 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL27635243 | 0.81 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL15132640 | 0.80 | FYN (0.52) | FYNCHEK1CHEK2 | |
| SCHEMBL386532 | 0.79 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL17954213 | 0.78 | SMN1; SMN2 (0.66) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 | |
| SCHEMBL12970151 | 0.78 | KDM1A (0.53) | NPC1RAB9ASMN1; SMN2KDM1AFYN | |
| SCHEMBL12970398 | 0.78 | CCR1 (0.54) | NPC1RAB9ASMN1; SMN2NFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| EP-3254317-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| WO-2016124304-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | NPC1 4039/4885RAB9A 2171/4885SMN1; SMN2 4799/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | NPC1 2761/4885RAB9A 1433/4885SMN1; SMN2 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.