Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | SQOR | Q9Y6N5 | 4/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19794450 | 0.92 | TGFBR1 (0.43) | TGFBR1MAPK14SQORPDK2GRM5 | |
| SCHEMBL18015380 | 0.92 | PDK2 (0.45) | TGFBR1PDK2GRM5DCTPP1NPC1 | |
| SCHEMBL23240025 | 0.88 | PDK2 (0.42) | TGFBR1MAPK14PDK2GRM5NPC1 | |
| SCHEMBL21202867 | 0.85 | PDK2 (0.42) | TGFBR1PDK2GRM5DCTPP1NPC1 | |
| SCHEMBL23239881 | 0.85 | CCR1 (0.44) | TGFBR1PDK2GRM5NPC1KDM4E | |
| SCHEMBL18015279 | 0.85 | PDK2 (0.42) | TGFBR1PDK2GRM5DCTPP1NPC1 | |
| SCHEMBL19794351 | 0.84 | PDK2 (0.41) | TGFBR1MAPK14PDK2GRM5DCTPP1 | |
| SCHEMBL19801320 | 0.83 | PDK2 (0.40) | TGFBR1PDK2DCTPP1NPC1KDM4E | |
| SCHEMBL19801347 | 0.83 | PDK2 (0.40) | TGFBR1PDK2GRM5DCTPP1NPC1 | |
| SCHEMBL18015275 | 0.83 | PDK2 (0.40) | TGFBR1PDK2GRM5DCTPP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| EP-3254317-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| WO-2016124304-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | TGFBR1 2080/4885MAPK14 4612/4885SQOR 637/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | TGFBR1 4348/4885MAPK14 4458/4885SQOR 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.