Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.35 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9616703 | 0.78 | LOX (0.41) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL18334440 | 0.76 | CHRM2 (0.34) | — | |
| SCHEMBL18334499 | 0.75 | GAA (0.33) | LMNAPTGS1ABCB11ALDH1A1TP53 | |
| SCHEMBL18334565 | 0.75 | GAA (0.33) | LMNAPTGS1ABCB11ALDH1A1TP53 | |
| SCHEMBL18334469 | 0.75 | GAA (0.33) | LMNAPTGS1ABCB11ALDH1A1TP53 | |
| SCHEMBL19829483 | 0.72 | LOX (0.39) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL18334437 | 0.70 | LMNA (0.38) | LMNAPTGS1ABCB11ALOX5ALDH1A1 | |
| SCHEMBL21694465 | 0.70 | LMNA (0.46) | LMNAPTGS1ABCB11LOXLOXL3 | |
| SCHEMBL18334495 | 0.69 | GAA (0.33) | LMNAALDH1A1GAAKDM4E | |
| SCHEMBL18334557 | 0.67 | TSHR (0.39) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123672-A1 | A METHOD OF TREATMENT AND COMPOUNDS FOR USE THEREIN | BAKER IDI HEART & DIABETES INSTITUTE HOLDINGS LIMITED (AU) | 2016-08-11 | — | — | WO | disclosed |