Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.58 |
| ▸ | KDM1A | O60341 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL1801687 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNA7CHRNA4KDM1AMAOB | |
| SCHEMBL929227 | 0.90 | CHRNB2 (0.67) | CHRNB2CHRNA7CHRNA4KDM1AMAOB | |
| Cadaverine Tartrate SCHEMBL1792404 | 0.86 | CHRNA7 (0.79) | CHRNB2CHRNA7CHRNA4 | |
| Cadaverine Tartrate SCHEMBL1792402 | 0.86 | CHRNA7 (0.79) | CHRNB2CHRNA7CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL6323991 | 0.80 | CHRNB2 (0.61) | CHRNB2CHRNA7CHRNA4KDM1AMAOB | |
| SCHEMBL6329173 | 0.79 | CHRNB2 (0.45) | CHRNB2CHRNA7CHRNA4KDM1AMAOB | |
| SCHEMBL929300 | 0.78 | CHRNA7 (0.67) | CHRNB2CHRNA7CHRNA4KDM1AMAOB | |
| SCHEMBL928224 | 0.77 | CHRNA7 (0.82) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL928223 | 0.75 | CHRNA7 (1.00) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL928803 | 0.75 | CHRNB2 (0.63) | CHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316836-A1 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors | Abbott Laboratories (US) | 2011-05-04 | — | — | EP | disclosed |
| CN-101189233-A | Substituted diazabicycloalkane derivatives as ligands for the alpha 7 nicotinic acetylcholine receptor | ABBOTT LAB (US) | 2008-05-28 | — | — | CN | disclosed |