Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 9/20 | 0.75 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.66 |
| ▸ | BTK | Q06187 | 6/20 | 0.63 |
| ▸ | EGFR | P00533 | 5/20 | 0.63 |
| ▸ | JAK3 | P52333 | 5/20 | 0.63 |
| ▸ | JAK2 | O60674 | 3/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | JAK1 | P23458 | 2/20 | 0.63 |
| ▸ | BLK | P51451 | 2/20 | 0.58 |
| ▸ | BMX | P51813 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10127730 | 0.91 | NUAK1 (0.80) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL18018907 | 0.87 | MAP3K7 (0.57) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL18018785 | 0.86 | MAP3K7 (1.00) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL18018867 | 0.84 | MAP3K7 (0.73) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL30672822 | 0.84 | NUAK1 (0.68) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL16370570 | 0.84 | NUAK1 (0.68) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL18018921 | 0.83 | MAP3K7 (0.78) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL16706359 | 0.83 | NUAK1 (0.68) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL30672915 | 0.82 | NUAK1 (0.66) | MAP3K7NUAK1BTKEGFRJAK3 | |
| SCHEMBL16371170 | 0.82 | NUAK1 (0.66) | MAP3K7NUAK1BTKEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210115055-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-22 | — | — | US | disclosed |
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10913744-B2 | LRRK2 inhibitors and methods of making and using the same | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| WO-2016130920-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115055-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | LRRK2, PARK7, PINK1 | MAP3K7 166/4885NUAK1 839/4885BTK 1150/4885 |
| US-10913744-B2 | LRRK2 inhibitors and methods of making and using the same | LRRK2, PARK7, PINK1 | MAP3K7 166/4885NUAK1 839/4885BTK 1150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.