Sugi Predict

Sugi Predict / Compounds / SCHEMBL18019130

SCHEMBL18019130

SCHEMBL18019130

CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.84

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ LARS1 Q9P2J5 10/20 0.84
▸ ADAMTS4 O75173 3/20 0.52
▸ MMP2 P08253 3/20 0.51
▸ MMP3 P08254 3/20 0.51
▸ MMP13 P45452 3/20 0.51
▸ MMP1 P03956 2/20 0.51
▸ MMP7 P09237 2/20 0.51
▸ MMP9 P14780 2/20 0.51
▸ TARS1 P26639 1/20 0.50
▸ CTSL P07711 1/20 0.50
▸ CTSS P25774 1/20 0.50
▸ CTSK P43235 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28717212 1.00 LARS1 (0.84) LARS1ADAMTS4MMP2MMP3MMP13
SCHEMBL18019131 0.92 LARS1 (1.00) LARS1TARS1CTSLCTSSCTSK
SCHEMBL28173973 0.92 LARS1 (1.00) LARS1TARS1CTSLCTSSCTSK
Hydrochloric Acid SCHEMBL28591957 0.90 LARS1 (0.97) LARS1MMP2TARS1CTSLCTSS
Hydrochloric Acid SCHEMBL28591958 0.90 LARS1 (0.97) LARS1MMP2TARS1CTSLCTSS
SCHEMBL18019129 0.90 LARS1 (1.00) LARS1TARS1CTSLCTSSCTSK
SCHEMBL19792904 0.86 LARS1 (0.78) LARS1ADAMTS4MMP2MMP3MMP13
SCHEMBL18019125 0.83 LARS1 (0.74) LARS1
SCHEMBL18019154 0.82 LARS1 (0.57) LARS1ADAMTS4MMP2MMP3MMP13
SCHEMBL18019184 0.82 LARS1 (1.00) LARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527152-A Biphenylsulfonamide compound and method for preventing and treating crop pests by using same 西北农林科技大学 2021-10-22 — — CN claimed
CN-113527152-A Biphenylsulfonamide compound and method for preventing and treating crop pests by using same 西北农林科技大学 2021-10-22 — — CN disclosed
US-11072581-B2 N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors Oxford Drug Design Limited (GB) 2021-07-27 — — US disclosed
US-20180022696-A1 NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS THE LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) 2018-01-25 — — US disclosed
US-20180022696-A1 NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS THE LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) 2018-01-25 — — US disclosed
WO-2016129983-A1 NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) 2016-08-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180022696-A1 NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS AARS1, GARS1, ASNS LARS1 72/4885ADAMTS4 2833/4885MMP2 3748/4885
US-11072581-B2 N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors AARS1, ASNS, GARS1 LARS1 77/4885ADAMTS4 2673/4885MMP2 3418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.