Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LARS1 | Q9P2J5 | 5/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 4/20 | 0.47 |
| ▸ | MMP3 | P08254 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | TARS1 | P26639 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18019130 | 0.82 | LARS1 (0.84) | LARS1ADAMTS4MMP2MMP9MMP3 | |
| SCHEMBL28717212 | 0.82 | LARS1 (0.84) | LARS1ADAMTS4MMP2MMP9MMP3 | |
| SCHEMBL18019110 | 0.82 | LARS1 (0.73) | LARS1CTSLCTSSCTSKTARS1 | |
| SCHEMBL17123491 | 0.77 | ALDH1A1 (0.66) | LARS1ADAMTS4MMP2MMP9MMP3 | |
| SCHEMBL18019131 | 0.73 | LARS1 (1.00) | LARS1CTSLCTSSCTSKTARS1 | |
| SCHEMBL28173973 | 0.73 | LARS1 (1.00) | LARS1CTSLCTSSCTSKTARS1 | |
| SCHEMBL3908561 | 0.73 | LARS1 (0.51) | LARS1ADAMTS4MMP2MMP9MMP3 | |
| SCHEMBL31086764 | 0.73 | MMP2 (0.71) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL18019129 | 0.72 | LARS1 (1.00) | LARS1CTSLCTSSCTSKTARS1 | |
| SCHEMBL31086926 | 0.72 | MMP2 (0.82) | ADAMTS4MMP2MMP9MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016129983-A1 | NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-08-18 | — | — | WO | disclosed |